Human papillomavirus type 33 DNA in breast cancer in Chinese.

Authors :: Yu Y
Morimoto T
Sasa M
Okazaki K
Harada Y
Fujiwara T
Irie Y
Takahashi E
Tanigami A
Izumi K
Source :: Breast cancer (Tokyo, Japan) [Breast Cancer] 2000 Jan; Vol. 7 (1), pp. 33-6.
Publication Year :: 2000
Abstract: Background: The association between human papillomavirus (HPV) and anogenital tumors, especially cervical cancer, is well documented. However, it remains unclear whether there is also a correlation between HPV infection and human breast cancer.<br />Methods: We used PCR and Southern blot hybridization to analyze HPV-related DNA specimens from 32 cases of invasive ductal carcinoma operated upon in the Shanghai region of China.<br />Results: DNA derived from HPV33 was detected in 14 cases (43.8%). No HPV16 or HPV18 DNA was detected in any of the cases in this study. This is the first report demonstrating a correlation between HPV33 infection and breast cancer.<br />Conclusions: Our results suggest that HPV33 infection may be involved in the pathogenesis of breast cancer in Chinese.