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RelB nuclear translocation regulates B cell MHC molecule, CD40 expression, and antigen-presenting cell function.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2000 Oct 10; Vol. 97 (21), pp. 11421-6. - Publication Year :
- 2000
-
Abstract
- Mice with targeted RelB mutations demonstrated an essential role for RelB in immune responses and in myeloid dendritic cell differentiation. Human studies suggested a more global transcriptional role in antigen presentation. Burkitt lymphoma cell lines were used as a model to examine the role of RelB in antigen presentation. After transient transfection of BJAB with RelB, strong nuclear expression of RelB-p50 heterodimers was associated with increased APC function and expression of CD40 and MHC class I. Antisense RelB in DG75 reduced antigen-presenting capacity and CD40-mediated up-regulation of MHC molecules. The data indicate that RelB transcriptional activity directly affects antigen presentation and CD40 synthesis. Stimulation of RelB transcriptional activity may provide a positive feedback loop for facilitating productive APC/T cell interactions.
- Subjects :
- Antigen-Presenting Cells drug effects
Cell Line
Humans
Oligonucleotides, Antisense pharmacology
Protein Transport
Proto-Oncogene Proteins genetics
Transcription Factor RelB
Transcription Factors genetics
Antigen-Presenting Cells immunology
B-Lymphocytes immunology
Cell Nucleus metabolism
Major Histocompatibility Complex
Proto-Oncogene Proteins metabolism
Transcription Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0027-8424
- Volume :
- 97
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 11027342
- Full Text :
- https://doi.org/10.1073/pnas.97.21.11421