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Type 2 diabetes and the metabolic syndrome in Japanese Americans.
- Source :
-
Diabetes research and clinical practice [Diabetes Res Clin Pract] 2000 Oct; Vol. 50 Suppl 2, pp. S73-6. - Publication Year :
- 2000
-
Abstract
- Japanese Americans have experienced a higher prevalence of type 2 diabetes than in Japan. Research conducted in Seattle suggests that lifestyle factors associated with 'westernization' play a role in bringing out this susceptibility to diabetes. These lifestyle factors include consumption of a diet higher in saturated fat and reduced physical activity. A consequence of this is the development of central (visceral) adiposity, insulin resistance, and other features associated with this insulin resistance metabolic syndrome, such as dyslipidemia (high triglycerides, low HDL-cholesterol, and small and dense LDL particles), hypertension, and coronary heart disease. We have postulated that the superimposition of insulin resistance upon a genetic background of reduced beta-cell reserve results in hyperglycemia and diabetes among Japanese Americans. This article reviews evidence that support this view.
Details
- Language :
- English
- ISSN :
- 0168-8227
- Volume :
- 50 Suppl 2
- Database :
- MEDLINE
- Journal :
- Diabetes research and clinical practice
- Publication Type :
- Academic Journal
- Accession number :
- 11024587
- Full Text :
- https://doi.org/10.1016/s0168-8227(00)00182-0