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Evaluation of a series of anticonvulsant 1,2,3,4-tetrahydroisoquinolinyl-benzamides.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2000 Aug; Vol. 8 (8), pp. 2085-94. - Publication Year :
- 2000
-
Abstract
- SAR studies around a series of N-(tetrahydroisoquinolinyl)-2-methoxybenzamides, identified by high-throughput screening at the novel SB-204269 binding site, have provided compounds such as 13, 29-33 with high affinity and excellent anticonvulsant activity in animal models.
- Subjects :
- Animals
Anticonvulsants chemical synthesis
Anticonvulsants metabolism
Benzamides chemical synthesis
Benzamides metabolism
Benzopyrans metabolism
Binding Sites
Brain Chemistry
Drug Evaluation, Preclinical
Isoquinolines chemical synthesis
Isoquinolines metabolism
Male
Mice
Models, Molecular
Molecular Structure
Radioligand Assay
Rats
Seizures drug therapy
Structure-Activity Relationship
Anticonvulsants chemistry
Anticonvulsants pharmacology
Benzamides chemistry
Benzamides pharmacology
Drug Design
Isoquinolines chemistry
Isoquinolines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0968-0896
- Volume :
- 8
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 11003154
- Full Text :
- https://doi.org/10.1016/s0968-0896(00)00149-8