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Environmental immunogens and T-cell-mediated responses in fibromyalgia: evidence for immune dysregulation and determinants of granuloma formation.
- Source :
-
Experimental and molecular pathology [Exp Mol Pathol] 2000 Oct; Vol. 69 (2), pp. 102-18. - Publication Year :
- 2000
-
Abstract
- Thirty-nine patients with fibromyalgia syndrome (FMS) according to American College of Rheumatology criteria were studied for cell-mediated sensitivity to environmental chemicals. Lymphocytes were tested by standard [(3)H]thymidine incorporation in vitro for T cell memory to 11 chemical substances. Concanavalin A (Con A) was used to demonstrate T cell proliferation. Controls were 25 contemporaneous healthy adults and 252 other concurrent standard controls without any aspect of FMS. Significantly higher (P < 0.01) stimulation indexes (SI) were found in FMS for aluminum, lead, and platinum; borderline higher (0.05 > P > 0.02) SI were found for cadmium and silicon. FMS patients showed sporadic responses to the specific substances tested, with no high-frequency result (>50%) and no obvious pattern. Mitogenic responses to Con A indicated some suppression of T cell functionality in FMS. Possible links between mitogenicity and immunogenic T cell proliferation, certain electrochemical specifics of granuloma formation, maintenance of connective tissue, and the fundamental nature of FMS are considered.<br /> (Copyright 2000 Academic Press.)
- Subjects :
- Adult
Aged
Antigens
Case-Control Studies
Concanavalin A pharmacology
Female
Granuloma etiology
Humans
In Vitro Techniques
Lymphocyte Activation
Male
Middle Aged
Siloxanes adverse effects
Fibromyalgia etiology
Fibromyalgia immunology
Granuloma immunology
Metals adverse effects
Metals immunology
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-4800
- Volume :
- 69
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Experimental and molecular pathology
- Publication Type :
- Academic Journal
- Accession number :
- 11001860
- Full Text :
- https://doi.org/10.1006/exmp.2000.2322