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Angiotensinogen T174M and M235T variants, sodium intake and hypertension among non-drinking, lean Japanese men and women.
- Source :
-
Journal of hypertension [J Hypertens] 2000 Sep; Vol. 18 (9), pp. 1197-206. - Publication Year :
- 2000
-
Abstract
- Objective: To examine the interaction of sodium intake with genetic variations of the angiotensinogen gene and hypertension.<br />Design: A community-based case-reference study.<br />Setting: Two rural Japanese communities.<br />Participants: Non-overweight and non-drinking Japanese men and women: 229 hypertensives and 229 age-, sex- and community-matched normotensives aged 32 to 83 years.<br />Methods: Polymorphisms of the angiotensinogen gene detected by an allele-specific polymerase chain reaction. A priori hypothesis is individuals with 174M (threonine-to-methionine substitution) or 235T (methionine-to-threonine substitution) allelic variations may have an elevated risk of hypertension when they have a high sodium intake, estimated by 24-h urine collection and a dietary questionnaire.<br />Results: The genotypic frequency of the haplotype including both the 174M and 235T alleles was higher among hypertensives than among normotensives (23 versus 14%, P= 0.02). The frequency of the 174M allele was specifically higher among hypertensives than normotensives (12 versus 7%, P=0.01), and the odds ratio of hypertension associated with the 174M (versus 174T) allele was 1.8 [95% confidence interval (CI) 1.1-3.0, P=0.01]. The frequency of the 235T allele did not vary between the two groups (80 versus 82%, P= 0.40). The relationship between the 174M allele and hypertension was more evident among persons who had higher urinary sodium excretion (> = 166 mmol/day) than those with lower excretion (< 166 mmol/day): odds ratio 2.5 (95% CI, 1.2-5.2), P=0.01 versus 1.5 (95% CI, 0.7-3.1), P= 0.31; P for interaction = 0.04, and this trend was primarily observed for early-onset hypertension (< 55 years at onset). A similar but nonsignificant association was observed when stratified using present and past sodium intake scores derived from questionnaires.<br />Conclusion: Angiotensinogen genotype may affect the development of early-onset hypertension among Japanese, particularly in those who have a high sodium intake.
- Subjects :
- Adult
Age of Onset
Aged
Aged, 80 and over
Alcohol Drinking
Blood Pressure drug effects
Body Weight
Case-Control Studies
DNA Primers
Female
Gene Frequency
Haplotypes
Humans
Japan
Male
Middle Aged
Odds Ratio
Renin-Angiotensin System genetics
Rural Population
Sodium, Dietary urine
Angiotensinogen genetics
Asian People genetics
Hypertension ethnology
Hypertension genetics
Polymorphism, Single Nucleotide
Sodium, Dietary administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0263-6352
- Volume :
- 18
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 10994750
- Full Text :
- https://doi.org/10.1097/00004872-200018090-00005