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Clinicopathologic study of Castleman's disease in Korea.
- Source :
-
Journal of Korean medical science [J Korean Med Sci] 2000 Aug; Vol. 15 (4), pp. 393-8. - Publication Year :
- 2000
-
Abstract
- Castleman's disease represents an atypical lymphoproliferative disorder, infrequently associated with various immunologic abnormalities or subsequent development of malignancy such as Kaposi sarcoma, malignant lymphoma and plasmacytoma. Its clinicopathologic features depend on various etiologic factors such as Kaposi sarcoma herpesvirus (KSHV), oversecretion of IL-6, adhesion molecule and follicular dendritic cell dysplasia, etc. To investigate the relationship of Castleman's disease (CD) and the above factors, we reviewed 22 cases of CD. Four cases of KSHV positive CD were detected, all multicentric, plasma cell type, and these cases displayed prominent vascular proliferation, characteristic 'Kaposi-like lesion'. IL-6 and CD54 positive mononuclear cells were scattered in interfollicular areas of KSHV positive cases. Follicular dendritic cell hyperplasia, vascular proliferation, expression of IL-6 and CD54 did not show any significant difference between solitary vs multicentric type, and plasma cell type vs hyaline vascular type. Our study suggests that KSHV positive CD reveals unique pathologic features, and the probable relationship of KSHV and IL-6 and CD54 is discussed.
- Subjects :
- Adolescent
Adult
Biomarkers
Castleman Disease classification
Castleman Disease epidemiology
Castleman Disease virology
Dendritic Cells, Follicular pathology
Epstein-Barr Virus Infections epidemiology
Epstein-Barr Virus Infections virology
Female
Germinal Center pathology
Herpesviridae Infections epidemiology
Herpesviridae Infections virology
Herpesvirus 4, Human isolation & purification
Herpesvirus 8, Human isolation & purification
Humans
Hyperplasia
Intercellular Adhesion Molecule-1 analysis
Interleukin-6 analysis
Korea epidemiology
Lymph Nodes chemistry
Lymph Nodes pathology
Lymph Nodes virology
Male
Middle Aged
Neovascularization, Pathologic
Receptors, Complement 3d analysis
Retrospective Studies
Tumor Virus Infections epidemiology
Tumor Virus Infections virology
Castleman Disease pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1011-8934
- Volume :
- 15
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of Korean medical science
- Publication Type :
- Academic Journal
- Accession number :
- 10983686
- Full Text :
- https://doi.org/10.3346/jkms.2000.15.4.393