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Antibodies to Orientia tsutsugamushi, Rickettsia typhi and spotted fever group rickettsiae among febrile patients in rural areas of Malaysia.
- Source :
-
Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2000 May-Jun; Vol. 94 (3), pp. 280-4. - Publication Year :
- 2000
-
Abstract
- A serosurvey was conducted in 1995-97 among 1596 febrile patients from 8 health centres in Malaysia for antibodies against Orientia tsutsugamushi (OT), Rickettsia typhi (RT) and TT118 spotted fever group rickettsiae (SFGR) by using an indirect immunoperoxidase assay. A total of 51.4% patients had antibody against at least 1 of those rickettsiae. Antibody to SFGR was most prevalent (42.5%), followed by RT (28.1%) and OT (24.9%). The seroprevalences of antibodies to SFGR, RT or OT alone were 12.4, 3.6 and 4.3%, respectively. Antibodies against more than 1 species of rickettsiae were presence in 31.1% of the patients, suggesting the possibility of co-infection, previous exposures or serological cross-reactivities. Seroprevalence of the various rickettsiae varied according to locality, with SFGR antibodies being the most prevalent in most areas. There was no significant association of prevalence of rickettsial antibody with gender. The seroprevalence of OT, SFGR and RT increased with patient age but an increase of antibody titre with age was not significant. Those working in the agricultural sectors had significantly higher seroprevalence of OT, SFGR and RT than those not related with agricultural activities. Scrub typhus remains a public health problem with an estimated annual attack rate of 18.5%. Tick typhus and murine typhus as shown in this serosurvey appear much more widespread than scrub typhus in this country.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Bacterial analysis
Child
Female
Fever epidemiology
Fever microbiology
Humans
Malaysia epidemiology
Male
Middle Aged
Prevalence
Rickettsia Infections diagnosis
Rickettsia Infections immunology
Rural Health statistics & numerical data
Scrub Typhus diagnosis
Scrub Typhus immunology
Orientia tsutsugamushi immunology
Rickettsia Infections epidemiology
Rickettsia typhi immunology
Scrub Typhus epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 0035-9203
- Volume :
- 94
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 10974999
- Full Text :
- https://doi.org/10.1016/s0035-9203(00)90322-5