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Combined chemoimmunotherapy and radiation therapy of inflammatory breast carcinoma.
- Source :
-
Journal of surgical oncology [J Surg Oncol] 1979; Vol. 11 (4), pp. 325-32. - Publication Year :
- 1979
-
Abstract
- Thirty-two patients with a diagnosis of primary inflammatory breast carcinoma were treated with combination chemoimmunotherapy consisting of 5-fluorouracil, doxorubicin hydrochloride (Adriamycin), and cyclophosphamide (FAC) plus BCG followed by radiation therapy. This group of patients was compared to a group of 32 consecutive historical controls treated with radiation therapy alone. The estimated mean disease-free interval for the FAC-BCG group was 16 months, compared to 9 months for the radiation therapy alone group (P less than 0.01). The estimated median survival for the FAC-BCG treated group was 24 months, compared to 18 months for the radiation therapy alone group (P = less than 0.03). The combined modality approach consisting of chemoimmunotherapy and radiation therapy significantly improved the disease-free interval and survival of patients with inflammatory breast carcinoma.
- Subjects :
- Adult
Aged
Antineoplastic Agents adverse effects
Cyclophosphamide administration & dosage
Doxorubicin administration & dosage
Drug Therapy, Combination
Female
Fluorouracil administration & dosage
Humans
Middle Aged
Radiotherapy, High-Energy
Recurrence
Remission, Spontaneous
Time Factors
Antineoplastic Agents administration & dosage
BCG Vaccine administration & dosage
Breast Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0022-4790
- Volume :
- 11
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of surgical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 109703
- Full Text :
- https://doi.org/10.1002/jso.2930110407