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The AMPA receptors of auditory neurons.
- Source :
-
Hearing research [Hear Res] 2000 Sep; Vol. 147 (1-2), pp. 77-91. - Publication Year :
- 2000
-
Abstract
- The ionotropic glutamate receptor (GluR) subtype known as the AMPA receptor, which mediates rapid excitatory synaptic transmission in many regions of the nervous system, is composed of four different protein subunits, termed GluRs 1-4. The functional properties of each AMPA receptor are determined by the relative levels of GluRs 1-4 and by post-transcriptional modifications of these proteins through mRNA editing and alternative exon splicing. The present paper reviews the published evidence for (1) localization of mRNAs and immunoreactivity for GluRs 1-4 in the cochlea and subcortical central nervous system auditory pathways of mammals and birds, and (2) involvement of AMPA receptors in synaptic transmission in the auditory system. Recent biochemical and electrophysiological evidence concerning the specialized properties of AMPA receptors on brainstem auditory neurons is also reviewed, along with data concerning how these properties emerge during normal development.
- Subjects :
- Animals
Auditory Pathways cytology
Basal Nucleus of Meynert cytology
Basal Nucleus of Meynert metabolism
Cochlear Nucleus cytology
Cochlear Nucleus metabolism
Ganglia cytology
Ganglia metabolism
Geniculate Bodies cytology
Geniculate Bodies metabolism
Inferior Colliculi cytology
Inferior Colliculi metabolism
Neurons metabolism
Olivary Nucleus cytology
Olivary Nucleus metabolism
RNA, Messenger genetics
RNA, Messenger metabolism
Receptors, AMPA chemistry
Receptors, AMPA genetics
Auditory Pathways metabolism
Receptors, AMPA metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0378-5955
- Volume :
- 147
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Hearing research
- Publication Type :
- Academic Journal
- Accession number :
- 10962175
- Full Text :
- https://doi.org/10.1016/s0378-5955(00)00122-2