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Cytotoxic saponins from bulbs of Allium porrum L.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2000 Aug; Vol. 48 (8), pp. 3455-62. - Publication Year :
- 2000
-
Abstract
- An extensive phytochemical analysis of the saponin content has been undertaken on leek, Allium porrum L., sown and collected at different seasons. As a result of this investigation, eight saponins (1-8) have been isolated, four of them (5-8) being novel compounds. Compounds 5 and 6, possessing the same tetrasaccharide moiety of compounds 1 and 3, display very unusual spirostane aglycones, 12-ketoporrigenin and 2,12-diketoporrigenin (named porrigenin C), respectively, recently isolated for the first time as free sapogenin in the same plant. Compounds 7 and 8 are rare cholestane bidesmosides possessing a di- and trisaccharide residues linked to a polyhydroxycholesterol aglycone, respectively. The structures of the isolated compounds have been determined by nondegradative spectroscopic analysis, mainly based on NMR. All the eight saponins isolated from leek were tested for their cytotoxic activity against two different cell lines in vitro, and compounds 1, 2, and 6 resulted particularly active.
- Subjects :
- Animals
Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic pharmacology
Carbohydrate Sequence
Drug Screening Assays, Antitumor
Mice
Molecular Sequence Data
Saponins chemistry
Saponins pharmacology
Tumor Cells, Cultured
Allium chemistry
Antineoplastic Agents, Phytogenic isolation & purification
Saponins isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0021-8561
- Volume :
- 48
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 10956133
- Full Text :
- https://doi.org/10.1021/jf000331v