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[Physiopathology of nephropathy studied with contrast media].
- Source :
-
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion [Rev Invest Clin] 2000 May-Jun; Vol. 52 (3), pp. 306-13. - Publication Year :
- 2000
-
Abstract
- For the technological advances in diagnostic and therapeutic procedures, the use of intravenous contrast media in the hospital is more and more frequent. It can produce acute renal failure secondary to its nephrotoxicity known as contrast media nephropathy. This review describes the pathophysiologic mechanisms of contrast media injury, including cytotoxicity caused by hyperosmoloarity of contrast media, the hemodynamic factors and the role of the renin-angiotensin system, prostaglandins, oxygen free radicals, endothelin-1, adenosine, nitric oxide and others. The understanding of this information is of vital importance for the development of prophylactic strategies for contrast media nephropathy.
- Subjects :
- Adenosine physiology
Endothelin-1 physiology
Free Radicals
Hemodynamics
Histamine physiology
Humans
Nitric Oxide physiology
Prostaglandins physiology
Reactive Oxygen Species physiology
Risk Factors
Contrast Media adverse effects
Kidney Diseases chemically induced
Kidney Diseases physiopathology
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0034-8376
- Volume :
- 52
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion
- Publication Type :
- Academic Journal
- Accession number :
- 10953614