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Intrathecal administration of neutralizing antibody against Fas ligand suppresses the progression of experimental autoimmune encephalomyelitis.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2000 Aug 18; Vol. 275 (1), pp. 164-8. - Publication Year :
- 2000
-
Abstract
- A therapy aimed at blocking the Fas/Fas ligand (FasL) system was investigated using a relapsing form of experimental autoimmune encephalomyelitis (EAE) in mice, an animal model of multiple sclerosis (MS). Intracisternal administration of neutralizing antibody against FasL during the progression phase of EAE significantly reduced the severity of the disease with milder inflammation and myelin breakdown in the central nervous system (CNS). These results raised the possibility that the Fas/FasL system might contribute to tissue destruction in the CNS in the acute phase of EAE and that the intrathecal administration of neutralizing antibody against FasL may be beneficial for suppression of the acute phase of MS.<br /> (Copyright 2000 Academic Press.)
- Subjects :
- Acute Disease
Animals
Antibodies immunology
Antibodies pharmacology
Central Nervous System drug effects
Central Nervous System immunology
Central Nervous System metabolism
Central Nervous System pathology
DNA Fragmentation
Disease Models, Animal
Disease Progression
Encephalomyelitis, Autoimmune, Experimental immunology
Encephalomyelitis, Autoimmune, Experimental metabolism
Fas Ligand Protein
Female
Histocytochemistry
In Situ Nick-End Labeling
Inflammation immunology
Injections, Spinal
Membrane Glycoproteins immunology
Mice
Mice, Inbred Strains
Multiple Sclerosis immunology
Multiple Sclerosis metabolism
Multiple Sclerosis pathology
Multiple Sclerosis therapy
Myelin Basic Protein immunology
Myelin Sheath immunology
Myelin Sheath metabolism
Antibodies administration & dosage
Antibodies therapeutic use
Encephalomyelitis, Autoimmune, Experimental pathology
Encephalomyelitis, Autoimmune, Experimental therapy
Membrane Glycoproteins antagonists & inhibitors
Membrane Glycoproteins physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0006-291X
- Volume :
- 275
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 10944459
- Full Text :
- https://doi.org/10.1006/bbrc.2000.3279