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Vasopressin and thirst in patients with posterior pituitary ectopia and hypopituitarism.
- Source :
-
Clinical endocrinology [Clin Endocrinol (Oxf)] 2000 Jul; Vol. 53 (1), pp. 77-83. - Publication Year :
- 2000
-
Abstract
- Objective: Partial diabetes insipidus has been documented in patients with congenital hypopituitarism and posterior pituitary ectopia, some cases being clinically silent except for enuresis. The objective of our study was to evaluate vasopressin (AVP) secretion and thirst appreciation in hypopituitary patients with posterior pituitary ectopia.<br />Patients: Twelve males and three females, aged between 13 and 38 years (median 19 years). Eleven had multiple pituitary deficiencies, adequately replaced at the time of the study, and four were only growth hormone deficient. None of the patients suffered from polyuria, polydipsia or nocturnal enuresis. We tested the patients with a 5% NaCl infusion. Five patients with abnormal vasopressin production were also tested with nitroprusside, which affects baroceptor vasopressin secretion.<br />Results: We found that only two out of 12 patients had normal AVP secretion. Thirst assessment showed severe hypodipsia in one patient, hyperdipsia in three out of 15 and more subtle abnormalities in two out of 15 patients. Concordance was found between osmotically and baroceptor-stimulated vasopressin.<br />Conclusions: Patients with posterior pituitary ectopia showed a high prevalence of subclinical subnormal vasopressin response to the osmolar stimulus and moreover an impairment of thirst appreciation. Our data on nonosmotically stimulated AVP release suggest the existence of a damage in the hypothalamic vasopressin secreting centres.
- Subjects :
- Adolescent
Adult
Female
Humans
Hypopituitarism blood
Hypopituitarism physiopathology
Male
Nitroprusside
Osmolar Concentration
Pituitary Gland, Posterior physiopathology
Saline Solution, Hypertonic
Vasodilator Agents
Hypopituitarism congenital
Pituitary Gland, Posterior abnormalities
Thirst physiology
Vasopressins blood
Subjects
Details
- Language :
- English
- ISSN :
- 0300-0664
- Volume :
- 53
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 10931083
- Full Text :
- https://doi.org/10.1046/j.1365-2265.2000.01030.x