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Hypergranular promyelocytic leukemia: correlation between morphology and chromosomal translocations including t(15;17) and t(11;17).
- Source :
-
Leukemia [Leukemia] 2000 Jul; Vol. 14 (7), pp. 1197-200. - Publication Year :
- 2000
-
Abstract
- The FAB group has reviewed 32 cases of promyelocytic leukemia and variant forms. By utilizing published criteria the ability to make a correct diagnosis by morphology with molecular genetic confirmation and to eliminate cases that did not have the PML/RARalpha rearrangement was excellent.
- Subjects :
- Antineoplastic Agents pharmacology
Antineoplastic Agents therapeutic use
Carboxylic Ester Hydrolases analysis
Cytoplasmic Granules enzymology
Humans
Leukemia, Promyelocytic, Acute diagnosis
Leukemia, Promyelocytic, Acute drug therapy
Leukemia, Promyelocytic, Acute pathology
Neoplasm Proteins analysis
Neoplasm Proteins genetics
Neoplastic Stem Cells enzymology
Oncogene Proteins, Fusion analysis
Oncogene Proteins, Fusion genetics
Peroxidase analysis
Staining and Labeling
Tretinoin pharmacology
Tretinoin therapeutic use
Chromosomes, Human, Pair 11 ultrastructure
Chromosomes, Human, Pair 15 ultrastructure
Chromosomes, Human, Pair 17 ultrastructure
Cytoplasmic Granules ultrastructure
Leukemia, Promyelocytic, Acute genetics
Neoplastic Stem Cells ultrastructure
Translocation, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 0887-6924
- Volume :
- 14
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Leukemia
- Publication Type :
- Academic Journal
- Accession number :
- 10914542
- Full Text :
- https://doi.org/10.1038/sj.leu.2401795