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Assessment in rats of the reproductive toxicity of gasoline from a gasoline vapor recovery unit.
- Source :
-
Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2000 Jul-Aug; Vol. 14 (4), pp. 337-53. - Publication Year :
- 2000
-
Abstract
- Gasoline (CAS 86290-81-5) is one of the world's largest volume commercial products. Although numerous toxicology studies have been conducted, the potential for reproductive toxicity has not been directly assessed. Accordingly, a two-generation reproductive toxicity study in rats was conducted to provide base data for hazard assessment and risk characterization. The test material, vapor recovery unit gasoline (68514-15-8), is the volatile fraction of formulated gasoline and the material with which humans are most likely to come in contact. The study was of standard design. Exposures were by inhalation at target concentrations of 5000, 10 000, and 20 000 mg/m(3). The highest exposure concentration was approximately 50% of the lower explosive limit and several orders of magnitude above anticipated exposure during refueling. There were no treatment-related clinical or systemic effects in the parental animals, and no microscopic changes other than hyaline droplet nephropathy in the kidneys of the male rats. None of the reproductive parameters were affected, and there were no deleterious effects on offspring survival and growth. The potential for endocrine modulation was also assessed by analysis of sperm count and quality as well as time to onset of developmental landmarks. No toxicologically important differences were found. Therefore, the NOAEL for reproductive toxicity in this study was > or =20 000 mg/m(3). The only systemic effects, in the kidneys of the male rats, were consistent with an alpha-2 u-globulin-mediated process. This is a male rat-specific effect and not relevant to human health risk assessment.
- Subjects :
- Administration, Inhalation
Animals
Animals, Newborn growth & development
Atmosphere Exposure Chambers
Body Weight drug effects
Estrus drug effects
Female
Gonads drug effects
Gonads pathology
Growth drug effects
Humans
Male
No-Observed-Adverse-Effect Level
Organ Size drug effects
Pregnancy
Rats
Rats, Sprague-Dawley
Respiratory System drug effects
Respiratory System pathology
Spermatozoa drug effects
Spermatozoa pathology
Air Pollutants, Occupational toxicity
Gasoline toxicity
Prenatal Exposure Delayed Effects
Subjects
Details
- Language :
- English
- ISSN :
- 0890-6238
- Volume :
- 14
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Reproductive toxicology (Elmsford, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 10908837
- Full Text :
- https://doi.org/10.1016/s0890-6238(00)00085-x