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[Possible mechanisms of polyuria in progressive chronic renal failure].
- Source :
-
Terapevticheskii arkhiv [Ter Arkh] 2000; Vol. 72 (6), pp. 15-20. - Publication Year :
- 2000
-
Abstract
- Aim: Elucidation of the role of saluresis and osmotic diuresis in renal function of patients with chronic renal failure.<br />Material and Methods: The trial included 68 subjects, among them 25 patients with chronic renal failure (CRF) of the third and fourth degree aged 16 to 72 years. Enzyme immunoassay was used to measure osmolality, sodium, potassium, magnesium, calcium and creatinine concentrations in the serum and urine as well as urine prostaglandin E2.<br />Results: Renal function was studied in CRF patients with a 75-90% fall of glomerular filtration rate. Creatinine clearance was 19.9 +/- 0.96, it varied in different patients from 10.6 to 29.7 ml/min. It is shown that diuresis does not correlate with the total ion excretion (Na+ plus K+)(r = 0.946, p < 0.0001). A correlation was found between excretion of these ions and Mg2+ ions this indicating location of reabsorption reduction in the thick ascending limb of Henle loop. In CRF patients (Na+ plus K+) excretion correlated with PGE2 excretion (r = 0.65, p < 0.0001).<br />Conclusion: It is suggested that at this stage of chronic renal failure the mechanism of a diuresis increase is not due to osmotic diuresis but rather to secretion of prostaglandin E2 which inhibits cation reabsorption and stimulates diuresis. Differences are considered between osmotic diuresis and different types of saluresis; their possible mechanisms are discussed.
- Subjects :
- Adolescent
Adult
Aged
Biomarkers blood
Biomarkers urine
Calcium blood
Calcium urine
Creatinine blood
Creatinine urine
Dinoprostone urine
Disease Progression
Humans
Kidney Failure, Chronic etiology
Kidney Failure, Chronic metabolism
Magnesium blood
Magnesium urine
Middle Aged
Natriuresis physiology
Nephrons physiopathology
Osmolar Concentration
Polyuria complications
Polyuria metabolism
Potassium blood
Potassium urine
Prognosis
Sodium blood
Sodium urine
Diuresis physiology
Kidney Failure, Chronic physiopathology
Nephrons metabolism
Polyuria physiopathology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0040-3660
- Volume :
- 72
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Terapevticheskii arkhiv
- Publication Type :
- Academic Journal
- Accession number :
- 10900642