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Antigen-specific and nonspecific mediators of T cell/B cell cooperation. I. Evidence for their production by different T cells.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 1975 Mar; Vol. 114 (3), pp. 1116-25. - Publication Year :
- 1975
-
Abstract
- Evidence is presented for two types of helper T cells in the mouse specific for a protein antigen, keyhole limpet hemocyanin (KLH). The first cell is able to help B cells respond to the hapten, trinitrophenyl (TNP), when coupled to KLH presumably through the participation of KLH-specific T cell factors. The second helper cell when stimulated with KLH is able to help B cells respond to red blood cell antigens, but not TNP-KLH, through the production of a non-antigen-specific factor. Both types of helper cells were shown to be present in the spleens of KLH-primed mice, although they occurred with different frequencies. They were shown to be different T cells by their segregation from each other in vitro at limiting dilution.
- Subjects :
- Animals
Antibody-Producing Cells
Cells, Cultured
Erythrocytes immunology
Female
Haptens
Hemolytic Plaque Technique
Horses immunology
Immunization
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Mollusca
Nitrophenols immunology
Perissodactyla immunology
Serum Albumin, Bovine
Sheep immunology
Spleen cytology
B-Lymphocytes immunology
Hemocyanins
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1767
- Volume :
- 114
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 1089726