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Interaction between CCK and a preload on reduction of food intake is mediated by CCK-A receptors in humans.
- Source :
-
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2000 Jul; Vol. 279 (1), pp. R189-95. - Publication Year :
- 2000
-
Abstract
- Cholecystokinin (CCK) interacts with neural signals to induce satiety in several species, but the mechanisms are unclear. We therefore tested the hypothesis that alimentary CCK (CCK-A) receptors mediate the interaction of CCK with an appetizer on food intake in humans. CCK octapeptide (CCK-8, 0.75 microgram infused over 10 min) or saline (placebo) with concomitant infusions of saline (placebo) or loxiglumide, a specific CCK-A antagonist, was infused into 16 healthy men with use of a double-blind, four-period design. All subjects received a standard 400-ml appetizer (amounting to 154 kcal) but were free to eat and drink thereafter as much as they wished. The effect of these infusions on feelings of hunger and satiety and on food intake was quantified. CCK-8 induced a reduction in calorie intake (P < 0.05) compared with saline. Furthermore, a decrease in hunger feelings (P < 0.05, saline-CCK-8 vs. all other treatments) and an increase in fullness were observed. These effects were antagonized for hunger and fullness by loxiglumide. We conclude that CCK-8 interacts with an appetizer to modulate satiety in humans. These effects are mediated by CCK-A receptors.
- Subjects :
- Adult
Cross-Over Studies
Double-Blind Method
Eating drug effects
Energy Intake drug effects
Energy Intake physiology
Humans
Hunger drug effects
Hunger physiology
Infusions, Intravenous
Male
Proglumide administration & dosage
Receptor, Cholecystokinin A
Receptors, Cholecystokinin antagonists & inhibitors
Satiety Response drug effects
Sincalide administration & dosage
Cholecystokinin blood
Eating physiology
Proglumide analogs & derivatives
Receptors, Cholecystokinin metabolism
Satiety Response physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0363-6119
- Volume :
- 279
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Regulatory, integrative and comparative physiology
- Publication Type :
- Academic Journal
- Accession number :
- 10896881
- Full Text :
- https://doi.org/10.1152/ajpregu.2000.279.1.R189