HLA-DRB genotypes in Japanese patients with renal cell carcinoma.

Authors :: Kojima Y
Takahara S
Nonomura N
Sada M
Tsuji T
Hatori M
Fujioka H
Kuroda H
Miki T
Okuyama A
Source :: Oncology [Oncology] 2000 Jun; Vol. 59 (1), pp. 57-62.
Publication Year :: 2000
Abstract: Objectives: Several clinical features, such as the spontaneous regression of some renal cell carcinoma (RCC) metastases after nephrectomy, suggest immune involvement in tumor destruction.<br />Patients and Methods: We investigated the role of genetic variation at the HLA class II loci in RCC by analyzing the HLA-DR antigen and HLA-DRB1, DRB3, DRB4 and DRB5 alleles in 55 patients using the polymerase chain rection.<br />Results: No statistically significant differences were observed in the frequency of the HLA-DR antigen or HLA-DRB3, DRB4, or DRB5 genes between the patients and a healthy control group. On the other hand, the HLA-DRB1*0403 and *1202 alleles were significantly more frequent in the patients than in the controls (p < 0.001 and p < 0.01, respectively).<br />Conclusion: RCC might be linked to these two alleles in Japanese patients.<br /> (Copyright 2000 S. Karger AG, Basel)