Start Over

Central 5-HT(4) receptors and drinking behavior.

Authors :: Castro L
De Castro-E-Silva E
Lima AK
Souza FS
Maldonado I
Macêdo DF
Ferreira MG
Santamaria GF
Bandeira IP
Amor AL
Carvalho FL
Rocha MA Jr
Oliveira IR
Fregoneze JB
Source :: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2000 Jun; Vol. 66 (2), pp. 443-8.
Publication Year :: 2000
Abstract: The aim of the present study was to investigate the effect of acute third ventricle injections of two different 5-HT(4) receptor antagonists, GR 113808 and SB 204070, on water intake in different situations. Injections of 80 nmol/rat of both GR 113808 and SB 204070 were unable to modify water intake in normohydrated rats. Pretreatment with GR 113808 (40 and 80 nmol/rat) and SB 204070 (80 and 160 nmol/rat) blunted water intake after third ventricle injections of angiotensin II (9.6 pmol/rat) compared to saline-pretreated controls. Pretreatment with 80 nmol/rat of both antagonists potentiated drinking induced by third ventricle injections of carbachol (11.0 nmol/rat) compared to saline-pretreated control. In all doses employed, none of the compounds was able to modify water intake in dehydrated rats. A separate control test using one-bottle taste aversion paradigm indicated that the reduction in water intake observed in some of the present experiments could not be attributed to a drug-induced malaise. It is suggested that central 5-HT(4) receptors exert a dualistic role on the control of water intake potentiating angiotensin II-induced drinking and inhibiting thirst induced by central cholinergic activation