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Intercellular adhesion molecule-1 (ICAM-1) in cervicovaginal fluid of women presenting with preterm labor: predictive value for preterm delivery.

Authors :
Marvin KW
Keelan JA
Coleman MA
McCowan LM
Zhou RL
Mitchell MD
Source :
American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2000 May; Vol. 43 (5), pp. 264-71.
Publication Year :
2000

Abstract

Problem: Clinically useful tests for the prediction and diagnosis of preterm labor and delivery remain to be established. We have hypothesized that soluble intercellular adhesion molecule-1 (sICAM-1) in the cervicovaginal fluid of women with preterm labor may be a useful diagnostic tool.<br />Method of Study: The cervicovaginal fluid of 103 women between 24(0) and 33(6) weeks gestation with preterm contractions and intact membranes was assayed for sICAM-1.<br />Results: Elevated sICAM-1 concentrations predicted short intervals to delivery (area under receiver operator characteristic (ROC) curves, 0.70-0.72 for delivery within 3, 7 and 10 days), with high specificity. Characteristics for delivery within 3 days at a 3 ng/mL threshold for a positive test were sensitivity 33.3%, specificity 98.9%, and positive and negative predictive values of 75.0% and 93.9%, respectively. Predictive ability was independent of and complementary to that of fetal fibronectin (fFN).<br />Conclusions: Measurement of sICAM-1 in cervicovaginal fluid has potential as a predictor of preterm delivery in women with symptoms of preterm labor, particularly in conjunction with fFN testing.

Details

Language :
English
ISSN :
1046-7408
Volume :
43
Issue :
5
Database :
MEDLINE
Journal :
American journal of reproductive immunology (New York, N.Y. : 1989)
Publication Type :
Academic Journal
Accession number :
10872605
Full Text :
https://doi.org/10.1111/j.8755-8920.2000.430504.x