Back to Search
Start Over
Synthesis of glycosylated polyethylenimine with reduced toxicity and high transfecting efficiency.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2000 Jun 05; Vol. 10 (11), pp. 1233-5. - Publication Year :
- 2000
-
Abstract
- A safe and efficient synthesis of glycosylated polyethylenimine using titanium (IV) isopropoxide and sodium borohydride has been carried out as a substitute for the highly toxic sodium cyanoborohydride method currently used. Poryplexes formed between DNA and the various glycosylated polyethylenimines appeared to be much less cytotoxic than polyethylenimine (PEI)/DNA polyplexes.
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 10
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 10866388
- Full Text :
- https://doi.org/10.1016/s0960-894x(00)00195-5