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[Localized bullous eruption after intravenous injection of aciclovir: toxic or immunoallergic mechanism?].
- Source :
-
Annales de dermatologie et de venereologie [Ann Dermatol Venereol] 2000 May; Vol. 127 (5), pp. 496-8. - Publication Year :
- 2000
-
Abstract
- Objective: To report a case of bullous eruption at and far from the site of aciclovir injection.<br />Case Report: A 50-year-old man was treated with intravenous aciclovir for Herpes simplex meningoencephalitis. Ten days after treatment onset, blisters appeared on his right forearm, at and far from the site of aciclovir injection.<br />Discussion: This adverse effect has not been frequently reported. To date, bullous eruptions were considered to result from extravasation of the aciclovir solution. In this case, an immunoallergic pattern was discussed with the presence of a histological leukocytoclastic vasculitis.
- Subjects :
- Acyclovir immunology
Antiviral Agents immunology
Blister immunology
Drug Eruptions immunology
Encephalitis, Herpes Simplex drug therapy
Forearm
Humans
Injections, Intravenous
Male
Middle Aged
Vasculitis, Leukocytoclastic, Cutaneous etiology
Acyclovir adverse effects
Antiviral Agents adverse effects
Blister chemically induced
Drug Eruptions etiology
Subjects
Details
- Language :
- French
- ISSN :
- 0151-9638
- Volume :
- 127
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Annales de dermatologie et de venereologie
- Publication Type :
- Academic Journal
- Accession number :
- 10863180