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The fatty acid transport function of fatty acid-binding proteins.
- Source :
-
Biochimica et biophysica acta [Biochim Biophys Acta] 2000 Jun 26; Vol. 1486 (1), pp. 28-44. - Publication Year :
- 2000
-
Abstract
- The intracellular fatty acid-binding proteins (FABPs) comprise a family of 14-15 kDa proteins which bind long-chain fatty acids. A role for FABPs in fatty acid transport has been hypothesized for several decades, and the accumulated indirect and correlative evidence is largely supportive of this proposed function. In recent years, a number of experimental approaches which more directly examine the transport function of FABPs have been taken. These include molecular level in vitro modeling of fatty acid transfer mechanisms, whole cell studies of fatty acid uptake and intracellular transfer following genetic manipulation of FABP type and amount, and an examination of cells and tissues from animals engineered to lack expression of specific FABPs. Collectively, data from these studies have provided strong support for defining the FABPs as fatty acid transport proteins. Further studies are necessary to elucidate the fundamental mechanisms by which cellular fatty acid trafficking is modulated by the FABPs.
- Subjects :
- Animals
Biological Transport
Carrier Proteins genetics
Cell Line drug effects
Cytoplasm metabolism
Dietary Fats metabolism
Fatty Acid-Binding Proteins
Intestine, Small metabolism
Intracellular Membranes metabolism
Liver metabolism
Models, Molecular
Mutation
Myelin P2 Protein genetics
Myocardium metabolism
Peroxisome Proliferators pharmacology
Structure-Activity Relationship
Carrier Proteins metabolism
Fatty Acids metabolism
Myelin P2 Protein metabolism
Neoplasm Proteins
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3002
- Volume :
- 1486
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta
- Publication Type :
- Academic Journal
- Accession number :
- 10856711
- Full Text :
- https://doi.org/10.1016/s1388-1981(00)00046-9