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Prostate-specific membrane antigen (PSMA)-specific monoclonal antibodies in the treatment of prostate and other cancers.
- Source :
-
Cancer metastasis reviews [Cancer Metastasis Rev] 1999; Vol. 18 (4), pp. 483-90. - Publication Year :
- 1999
-
Abstract
- Prostate-specific membrane antigen (PSMA) is a cell surface glycoprotein that is expressed by prostate epithelial cells. PSMA-specific monoclonal antibodies have been utilized to characterize the biologic function and in vivo biodistribution of PSMA. PSMA is an attractive target protein for monoclonal antibody directed imaging or therapeutics for prostate cancer since its expression is relatively restricted to prostate epithelial cells and is over-expressed in prostate cancer, including in advanced stages. Currently, clinical usage of PSMA specific monoclonal antibodies has been limited to diagnostic immunohistochemistry and imaging of patients with prostate cancer. Novel applications for these antibodies will be discussed.
- Subjects :
- Antibody Specificity
Antigens, Neoplasm immunology
Glutamate Carboxypeptidase II
Humans
Immunohistochemistry
Male
Neoplasms diagnosis
Antibodies, Monoclonal therapeutic use
Antigens, Surface
Carboxypeptidases immunology
Neoplasms drug therapy
Prostatic Neoplasms diagnosis
Prostatic Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0167-7659
- Volume :
- 18
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cancer metastasis reviews
- Publication Type :
- Academic Journal
- Accession number :
- 10855791
- Full Text :
- https://doi.org/10.1023/a:1006308826967