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Junctional biases in the naive TCR repertoire control the CTL response to an immunodominant determinant of HSV-1.
- Source :
-
Immunity [Immunity] 2000 May; Vol. 12 (5), pp. 547-56. - Publication Year :
- 2000
-
Abstract
- The enormous diversity of the T cell pool makes it difficult to determine whether inherent biases in the naive TCR repertoire can influence T cell responsiveness. In C57BL/6 mice the cytotoxic T lymphocyte response to an immunodominant HSV-1 determinant (gB) is characterized by a prominent bias in Vbeta element usage, associated with a conserved and preferentially D element-encoded CDR3 sequence. Comparison of naive and gB-specific T cell populations revealed a similar enrichment of germline D element-encoded CDR3 sequences in the preimmune repertoire. Strikingly, eliminating the germline coding of the gB-specific CDR3 sequence caused an almost complete loss of the dominant subset of gB-specific T cells, illustrating that CDR3 biases can significantly alter both the composition and strength of an immune response.
Details
- Language :
- English
- ISSN :
- 1074-7613
- Volume :
- 12
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Immunity
- Publication Type :
- Academic Journal
- Accession number :
- 10843387
- Full Text :
- https://doi.org/10.1016/s1074-7613(00)80206-x