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Anti-AIDS agents part 41: synthesis and anti-HIV activity of 3',4'-di-o-(-)-camphanoyl-(+)-cis-khellactone (DCK) lactam analogues.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2000 May 15; Vol. 10 (10), pp. 1003-5. - Publication Year :
- 2000
-
Abstract
- DCK lactam analogues were synthesized and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. 4-Methyl-DCK lactam (11a) exhibited potent anti-HIV activity with EC50 and therapeutic index values of 0.00024 microM and 119,333, respectively.
- Subjects :
- Biochemistry methods
Camphor chemical synthesis
Camphor pharmacology
Drug Evaluation, Preclinical methods
Humans
Lactams chemistry
Lymphocytes drug effects
Lymphocytes virology
Structure-Activity Relationship
Anti-HIV Agents chemical synthesis
Anti-HIV Agents pharmacology
Bridged Bicyclo Compounds, Heterocyclic chemistry
Bridged Bicyclo Compounds, Heterocyclic pharmacology
Camphor analogs & derivatives
Coumarins chemistry
Coumarins pharmacology
Quinolones chemical synthesis
Quinolones pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 10
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 10843202
- Full Text :
- https://doi.org/10.1016/s0960-894x(00)00126-8