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[An analysis of 3H-tamoxifen binding with the cell plasma membranes of the rat uterus].
- Source :
-
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2000 Mar-Apr; Vol. 63 (2), pp. 51-3. - Publication Year :
- 2000
-
Abstract
- The effect of phencarol, ranitidine, propranolol, atropine, and diethylstilbestrol (known as modulators of the tamoxifen-binding sites in plasma membranes) on the 3H-tamoxifen binding to the plasma membrane fraction of white rat uterine cells was studied by determining the amounts of estradiol and H1- and H2-receptors. The interaction of tamoxifen with various receptors of uterine cells may be significant for evaluation of the tumor activity of this compound.
- Subjects :
- Animals
Cell Membrane drug effects
Cell Membrane metabolism
Drug Interactions
Female
Ligands
Rats
Receptors, Estradiol drug effects
Receptors, Estradiol metabolism
Statistics, Nonparametric
Tritium
Uterus drug effects
Antineoplastic Agents, Hormonal pharmacokinetics
Tamoxifen pharmacokinetics
Uterus metabolism
Subjects
Details
- Language :
- Russian
- ISSN :
- 0869-2092
- Volume :
- 63
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Eksperimental'naia i klinicheskaia farmakologiia
- Publication Type :
- Academic Journal
- Accession number :
- 10834095