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[A pilot study of irinotecan hydrochloride for metastatic breast cancer--efficacy as a salvage therapy].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2000 May; Vol. 27 (5), pp. 723-7. - Publication Year :
- 2000
-
Abstract
- From April 1996 through 1998, we treated twelve metastatic breast cancer patients with CPT-11 100 mg/m2 given on day 1, 8, and 15. All patients had received prior chemotherapy including anthracycline, and also another schedule such as MMC-VDS or HDMTX-5-FU. CPT-11 was well tolerated. One CR, two PR, and two long NC were achieved. Grade 3 leukocytopenia occurred in 2 patients. Grade 1 diarrhea occurred in 3 patients. According to the Kaplan-Meier method, the 50% survival was 354 days. In spite of intense prior chemotherapy, the treatment results with CPT-11 were satisfactory for anthracycline resistant metastatic breast cancer.
- Subjects :
- Adult
Aged
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Bone Neoplasms secondary
Breast Neoplasms pathology
Breast Neoplasms surgery
Camptothecin therapeutic use
Combined Modality Therapy
Drug Administration Schedule
Female
Humans
Irinotecan
Lymphatic Metastasis
Middle Aged
Pilot Projects
Salvage Therapy
Antineoplastic Agents, Phytogenic therapeutic use
Breast Neoplasms drug therapy
Camptothecin analogs & derivatives
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 27
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 10832441