Back to Search
Start Over
Hepatitis C virus in non-Hodgkin's lymphoma. A reappraisal after a prospective case-control study of 300 patients. Lombart Study Group of HCV-Lymphoma.
- Source :
-
American journal of hematology [Am J Hematol] 2000 Jun; Vol. 64 (2), pp. 95-100. - Publication Year :
- 2000
-
Abstract
- It is widely thought, but not yet explained, that there might be a pathogenetic link between the infection of hepatitis C virus (HCV) and the onset of B non-Hodgkin's lymphoma (NHL). We studied the prevalence of serum anti-HCV antibodies among 300 NHL comparing it with the prevalence among 600 age- and sex-matched non-neoplastic subjects as controls, 247 patients with non-lymphomatous neoplasm, and 122 patients treated with immunosuppressive agents. We found a prevalence of 0.16 among NHL and 0.085 among controls and non-lymphomatous patients. Although the difference was statistically significant (P < 0.001), the odds ratio was 2.049 and its confidence intervals included the equality. The HCV prevalence was independent of NHL subset, and the genotypes distribution was the same among NHL and controls. We disclosed a HBsAg prevalence of 0.077 in NHL versus 0.008 in controls (P < 0.001) with an odds ratio of 9.9. We do not believe that these findings support the hypothesis of an HCV pathogenetic role in lymphomagenesis because (i) the risk of previous infection is marginally higher in NHL than in controls, (ii) a typical genotype distribution is lacking, as is a NHL clinico-histological feature associated with HCV, and (iii) the higher prevalence of viral infection is not specific as witnessed by the high HBsAg prevalence.<br /> (Copyright 2000 Wiley-Liss, Inc.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Autoimmune Diseases drug therapy
Autoimmune Diseases immunology
Autoimmune Diseases virology
Case-Control Studies
Female
Genotype
Hepacivirus genetics
Hepacivirus immunology
Hepatitis B Surface Antigens analysis
Hepatitis C Antibodies analysis
Humans
Immunosuppressive Agents therapeutic use
Male
Middle Aged
Neoplasms immunology
Neoplasms virology
Prospective Studies
RNA, Viral analysis
Reference Values
Hepacivirus isolation & purification
Lymphoma, Non-Hodgkin virology
Subjects
Details
- Language :
- English
- ISSN :
- 0361-8609
- Volume :
- 64
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- American journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 10814987
- Full Text :
- https://doi.org/10.1002/(sici)1096-8652(200006)64:2<95::aid-ajh4>3.0.co;2-a