Biomimetic Fe(II)-mediated degradation of arteflene (Ro-42-1611). The first EPR spin-trapping evidence for the previously postulated secondary carbon-centered cyclohexyl radical.

Subjects

Subjects :

Alkylation
Animals
Antimalarials chemistry
Antimalarials pharmacology
Benzenesulfonates
Bridged Bicyclo Compounds, Heterocyclic pharmacology
Cyclohexanes chemistry
Drugs, Chinese Herbal chemistry
Drugs, Chinese Herbal metabolism
Drugs, Chinese Herbal pharmacology
Electron Spin Resonance Spectroscopy
Free Radicals chemistry
Free Radicals metabolism
Heme chemistry
Heme metabolism
Magnetic Resonance Spectroscopy
Nitroso Compounds
Oxidation-Reduction
Plasmodium falciparum drug effects
Spin Labels
Styrenes pharmacology
Antimalarials metabolism
Artemisinins
Bridged Bicyclo Compounds, Heterocyclic chemistry
Bridged Bicyclo Compounds, Heterocyclic metabolism
Cyclohexanes metabolism
Ferrous Compounds metabolism
Styrenes chemistry
Styrenes metabolism

Details

Language :

English

ISSN :

0022-3263

Volume :

65

Issue :

5

Database :

MEDLINE

Journal :

The Journal of organic chemistry

Publication Type :

Academic Journal

Accession number :

10814129

Full Text :

https://doi.org/10.1021/jo991585m