[Serotonin metabolism in the rat brain during water deprivation and hydration].

Authors :: Popova NK
Ivanova LN
Amstislavskaia TG
Melidi NN
Naumenko KS
Maslova LN
Bulygina VV
Source :: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova [Ross Fiziol Zh Im I M Sechenova] 2000 Feb; Vol. 86 (2), pp. 140-7.
Publication Year :: 2000
Abstract: Water deprivation (WD) decreased the serotonin (5-HT) level and significantly increased the 5-hydroxyindoleacetic acid (5-HIAA) in the rat midbrain and hypothalamus, the catabolic 5-HIAA/5-HT ratio increasing three-fold. Hydration (H) produced a moderate increase in the 5-HT and 5-HIAA levels in the hypothalamus with no changes in the 5-HIAA/5-HT ratio. Hydration exerted no significant effect upon the 5-HT level and metabolism in the midbrain. A two-fold increase of corticosterone concentration in water deprivation and its decrease in hydration were shown to occur in peripheral blood plasma.