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Expression of the adhesion molecules CD49d and CD49e on G-CSF-mobilized CD34+ cells of patients with solid tumors or non-Hodgkin's and Hodgkin's lymphoma and of healthy donors is inversely correlated with the amount of mobilized CD34+ cells.
- Source :
-
Journal of hematotherapy & stem cell research [J Hematother Stem Cell Res] 1999 Oct; Vol. 8 (5), pp. 539-46. - Publication Year :
- 1999
-
Abstract
- The yield of CD34+ PBPC and colony-forming units-granulocyte-macrophage (CFU-GM) in leukapheresis products and the expression of the adhesion molecules CD11a, CD31, CD49d, CD49e, CD54, CD58, CD62L, c-kit (CD117), Thy-1 (CD90), CD33, CD38, and HLA-DR on CD34+ PBPC were analyzed in patients with cancer of the testis (n = 10), breast cancer (n = 10), Hodgkin's disease (n = 20), high-grade (n = 20) and low-grade (n = 20) non-Hodgkin's lymphoma, and healthy donors (n = 20) undergoing G-CSF (filgrastim)-stimulated PBPC mobilization. For each disease entity, G-CSF was administered in two different doses, 10 microg G-CSF/kg body weight (BW)/day s.c. vs. 24 microg G-CSF/kg BW s.c./day in steady-state condition. Data were compared for each dose group separately. Patients with cancer of the testis and breast cancer mobilized significantly more CD34+ cells than patients with high-grade and low-grade non-Hodgkin's lymphoma and Hodgkin's disease (p<0.05). Correspondingly, expression of CD49d on CD34+ PBPC was significantly lower in the same patients with cancer of the testis compared with high-grade and low-grade non-Hodgkin's lymphoma and Hodgkins' disease and in patients with breast cancer compared with high-grade and low-grade non-Hodgkin's lymphoma, Hodgkins's disease, and healthy donors. Similar results were obtained for CD49e. These data suggest that the expression of the adhesion molecules CD49d and CD49e on G-CSF-mobilized CD34+ cells of patients with solid tumors, non-Hodgkin's lymphoma, Hodgkin's disease, and healthy donors is inversely correlated with the amount of mobilized CD34+ cells.
- Subjects :
- Adolescent
Adult
Antigens, CD analysis
Antigens, CD34 analysis
Breast Neoplasms immunology
Breast Neoplasms therapy
Colony-Forming Units Assay
Female
Filgrastim
Granulocyte Colony-Stimulating Factor pharmacology
Hematopoietic Stem Cells cytology
Hematopoietic Stem Cells pathology
Hodgkin Disease immunology
Hodgkin Disease therapy
Humans
Integrin alpha4
Integrin alpha5
Integrins analysis
Lymphoma, Non-Hodgkin immunology
Lymphoma, Non-Hodgkin therapy
Male
Middle Aged
Recombinant Proteins
Reference Values
Testicular Neoplasms immunology
Testicular Neoplasms therapy
Breast Neoplasms pathology
Cell Adhesion Molecules analysis
Granulocyte Colony-Stimulating Factor therapeutic use
Hematopoietic Stem Cell Mobilization methods
Hematopoietic Stem Cells immunology
Hodgkin Disease pathology
Lymphoma, Non-Hodgkin pathology
Testicular Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1525-8165
- Volume :
- 8
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of hematotherapy & stem cell research
- Publication Type :
- Academic Journal
- Accession number :
- 10791904
- Full Text :
- https://doi.org/10.1089/152581699319984