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Chronic interstitial lung disease due to Epstein-Barr virus infection in two infants.
- Source :
-
The European respiratory journal [Eur Respir J] 2000 Apr; Vol. 15 (4), pp. 803-6. - Publication Year :
- 2000
-
Abstract
- This case study reports on two infants, 5 and 6 months of age, respectively, with chronic interstitial lung disease who presented with failure to thrive, tachypnoea, rales and mild hypoxaemia. Epstein-Barr virus (EBV) was detected by in situ hybridization in lung biopsy specimens and by EBV-deoxyribonucleic acid-polymerase chain reaction (PCR) in bronchoalveolar lavage (BAL) fluid in one patient and by in situ hybridization and PCR analysis in BAL fluid in the second patient. There was serological evidence of immunoglobulin G antibodies to EBV capsid antigen by indirect immunofluorescence in both patients. After 7 months of respiratory symptoms one patient was successfully treated with a 10 day course of intravenous ganciclovir followed by oral acyclovir for 20 days. The other patient became symptom free after 3.5 months of respiratory symptoms, without any specific antiviral medication. During a follow-up of 2 and 1.5 yrs, respectively, both infants remained symptom free and showed normal physical development.
- Subjects :
- Antiviral Agents administration & dosage
Biopsy, Needle
Chronic Disease
Follow-Up Studies
Ganciclovir administration & dosage
Humans
Infant
Lung Diseases, Interstitial drug therapy
Lung Diseases, Interstitial pathology
Male
Treatment Outcome
Epstein-Barr Virus Infections complications
Epstein-Barr Virus Infections diagnosis
Herpesvirus 4, Human isolation & purification
Lung Diseases, Interstitial virology
Subjects
Details
- Language :
- English
- ISSN :
- 0903-1936
- Volume :
- 15
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The European respiratory journal
- Publication Type :
- Academic Journal
- Accession number :
- 10780777
- Full Text :
- https://doi.org/10.1034/j.1399-3003.2000.15d28.x