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Activation of transcription factors NF-kappaB and NF-IL-6 by human immunodeficiency virus type 1 protein R (Vpr) induces interleukin-8 expression.

Authors :
Roux P
Alfieri C
Hrimech M
Cohen EA
Tanner JE
Source :
Journal of virology [J Virol] 2000 May; Vol. 74 (10), pp. 4658-65.
Publication Year :
2000

Abstract

Human immunodeficiency virus (HIV)-positive individuals express elevated levels of interleukin-8 (IL-8), which is believed to be responsible for some of the clinical manifestations occurring during AIDS. We report here that virion-derived HIV type 1 (HIV-1) protein R (Vpr) increased IL-8 expression in primary T cells and macrophages, as well as in the T-cell line Jurkat, the monocytic cell line U937, and the epithelial cell line A549. Vpr appeared to increase IL-8 expression and IL-8 promoter activity by activating transcription factors NF-kappaB and NF-IL-6. Elevated Vpr was also shown to increase transcription of the NF-kappaB and NF-IL-6 enhancer-containing viral promoters for HIV, cytomegalovirus, and simian virus 40, as well as increase the expression of IL-6 and IL-10 in primary macrophages and in A549 cells, tumor necrosis factor alpha expression in primary T cells, and IL-6 and gamma interferon expression in U937 cells. These results suggest a new role for Vpr in the pathogenesis of HIV infection, namely, the activation of transcription factors NF-IL-6 and NF-kappaB.

Details

Language :
English
ISSN :
0022-538X
Volume :
74
Issue :
10
Database :
MEDLINE
Journal :
Journal of virology
Publication Type :
Academic Journal
Accession number :
10775602
Full Text :
https://doi.org/10.1128/jvi.74.10.4658-4665.2000