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Effect of subchronic antidepressant treatments on behavioral, neurochemical, and endocrine changes in the forced-swim test.
- Source :
-
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2000 Apr; Vol. 65 (4), pp. 591-7. - Publication Year :
- 2000
-
Abstract
- The purpose of the present study was to examine the effect of subchronic treatment (24 days) with antidepressants displaying differential effects on noradrenaline and serotonin reuptake, on behavior, neurochemistry, and hypothalamic-pituitary-adrenal (HPA) axis activity following FST exposure in the rat. Desipramine (7.5 mg/kg, IP) significantly decreased immobility in the FST, whilst paroxetine (7.5 mg/kg IP) and venlafaxine (10 mg/kg, IP) were without effect. Nonetheless, treatment with all three antidepressants significantly attenuated stress-related increases in amygdaloid and cortical serotonin turnover. Of the three antidepressants examined, only desipramine attenuated the stress-associated elevation in serum corticosterone. In conclusion, although FST-induced increases in serotonin turnover in the frontal cortex and amygdala were attenuated following treatment with all three antidepressants, FST-induced behavioral changes and increased HPA axis activity were normalized only following desipramine treatment. In addition, these results suggest that neurochemical mechanisms independent of increased serotonergic activity subserve the normalization of behavior and HPA axis responses in the FST. These data also add to our understanding of the interactions between antidepressants and stress-induced behavioral, neurochemical, and endocrine alterations, and illustrates important differences between classes of antidepressants.
- Subjects :
- Amygdala drug effects
Amygdala metabolism
Animals
Antidepressive Agents, Second-Generation pharmacology
Antidepressive Agents, Tricyclic pharmacology
Biogenic Amines metabolism
Cerebral Cortex drug effects
Cerebral Cortex metabolism
Corticosterone blood
Cyclohexanols pharmacology
Desipramine pharmacology
Hypothalamo-Hypophyseal System drug effects
Hypothalamo-Hypophyseal System physiology
Male
Motor Activity drug effects
Paroxetine pharmacology
Rats
Rats, Sprague-Dawley
Serotonin metabolism
Venlafaxine Hydrochloride
Antidepressive Agents pharmacology
Behavior, Animal drug effects
Brain Chemistry drug effects
Depressive Disorder psychology
Hormones blood
Swimming psychology
Subjects
Details
- Language :
- English
- ISSN :
- 0091-3057
- Volume :
- 65
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Pharmacology, biochemistry, and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 10764911
- Full Text :
- https://doi.org/10.1016/s0091-3057(99)00192-6