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The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans.
- Source :
-
Gut [Gut] 2000 May; Vol. 46 (5), pp. 688-693. - Publication Year :
- 2000
-
Abstract
- Background and Aims: The mechanism of intraduodenal fat induced inhibition of food intake is still unclear. Therefore, we tested the ability of duodenal fatty acids to suppress food intake at a lunchtime meal; in addition, we were interested to test if these effects were mediated by cholecystokinin (CCK) A receptors.<br />Subjects and Methods: Three sequential double blind, three period crossover studies were performed in 12 healthy males each: (1) subjects received intraduodenal fat with or without 120 mg of tetrahydrolipstatin, an inhibitor of gastrointestinal lipases, or saline; (2) volunteers received intraduodenal long chain fatty acids, medium chain fatty acids, or saline; (3) subjects received long chain fatty acids or saline together with concomitant intravenous infusions of saline or loxiglumide, a specific CCK-A receptor antagonist. The effect of these treatments on food intake and feelings of hunger was quantified.<br />Results: Intraduodenal fat perfusion significantly (p<0.05) reduced calorie intake. Inhibition of fat hydrolysis abolished this effect. Only long chain fatty acids significantly (p<0.05) decreased calorie intake, whereas medium chain fatty acids were ineffective. Infusion of loxiglumide abolished the effect of long chain fatty acids.<br />Conclusions: Generation of long chain fatty acids through hydrolysis of fat is a critical step for fat induced inhibition of food intake; the signal is mediated via CCK-A receptors.
- Subjects :
- Adult
Cross-Over Studies
Double-Blind Method
Energy Intake
Hormone Antagonists pharmacology
Humans
Hunger physiology
Male
Proglumide analogs & derivatives
Proglumide pharmacology
Receptors, Cholecystokinin antagonists & inhibitors
Receptors, Cholecystokinin physiology
Cholecystokinin metabolism
Duodenum metabolism
Eating physiology
Fatty Acids physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0017-5749
- Volume :
- 46
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Gut
- Publication Type :
- Academic Journal
- Accession number :
- 10764713
- Full Text :
- https://doi.org/10.1136/gut.46.5.689