Back to Search
Start Over
Hyperthermia enhances the response of paclitaxel and radiation in a mouse adenocarcinoma.
- Source :
-
International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 1999 May 01; Vol. 44 (2), pp. 407-12. - Publication Year :
- 1999
-
Abstract
- Purpose: The aim of our study was to investigate if the efficacy of paclitaxel and paclitaxel-radiation treatments in vivo could be enhanced by hyperthermia.<br />Materials and Methods: Paclitaxel was administered i.p. in doses from 30 to 60 mg/kg b.w. to (C3D2F1) mice bearing spontaneous mammary carcinoma. Local hyperthermia (41 degrees, 42 degrees, 43 degrees C) was carried out by immersing tumor-bearing legs in a water bath for 1 h. Single X-ray treatments from 10 to 90 Gy were performed. Tumor growth delay (TGD) or tumor control dose (TCD(50), radiation dose needed to induce local tumor control in 50% of irradiated animals) were the endpoints.<br />Results: A significant increase of dose-dependent growth delay was observed in paclitaxel and 43 degrees C hyperthermia combined treatments, and a superadditive effect was seen with paclitaxel 45 mg/kg. Combined treatments with hyperthermia at 41 degrees and 42 degrees C were less effective. Administration of paclitaxel 24 h, 4 h, and 15 min before or 15 min and 4 h after hyperthermic treatments produced similar results (TGDs varying from 22.1 to 17 days), and administering paclitaxel 48 h before or 24 h after hyperthermic treatments decreased TGDs (about 10 days). Trimodality treatment (paclitaxel 45 mg/kg, hyperthermia, and X-ray), with a TCD(50) of 14. 1 Gy, in respect to the TCD(50) of 53.1 obtained with X-ray alone, was the most effective.<br />Conclusions: Hyperthermia enhanced the effectiveness of paclitaxel in all the tested protocols. Our results show a superadditive effect of paclitaxel 45 mg/kg combined with a hyperthermic treatment of 1 h at 43 degrees C. Trimodality treatment, evaluated in terms of percentage of cures, shows a very high enhancement ratio.
- Subjects :
- Analysis of Variance
Animals
Combined Modality Therapy
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Screening Assays, Antitumor
Female
Mammary Neoplasms, Animal drug therapy
Mammary Neoplasms, Animal radiotherapy
Mice
Radiobiology
Antineoplastic Agents, Phytogenic pharmacology
Hyperthermia, Induced
Mammary Neoplasms, Animal therapy
Paclitaxel pharmacology
Radiation-Sensitizing Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0360-3016
- Volume :
- 44
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of radiation oncology, biology, physics
- Publication Type :
- Academic Journal
- Accession number :
- 10760437
- Full Text :
- https://doi.org/10.1016/s0360-3016(99)00008-5