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Multicentre, double-blind, comparison of fluvoxamine and clomipramine in the treatment of obsessive-compulsive disorder.
- Source :
-
International clinical psychopharmacology [Int Clin Psychopharmacol] 2000 Mar; Vol. 15 (2), pp. 69-76. - Publication Year :
- 2000
-
Abstract
- The aim of this prospectively randomized, double-blind, parallel group, multicentre study was to compare the efficacy and tolerability of fluvoxamine and clomipramine in patients suffering from obsessive-compulsive disorder (OCD) (DSM-III-R). Fourteen centres participated in this trial. Sixty-eight patients were randomized to receive fluvoxamine and 65 to receive clomipramine. The duration of the study was 10 weeks. The two treatment groups showed a marked improvement of obsessive-compulsive symptomatology, as determined by the Yale-Brown Obsessive-Compulsive Scale, the National Institute of Mental Health Obsessive-Compulsive Global Scale and Clinical Global Impression. No statistically significant differences were found between fluvoxamine and clomipramine in terms of efficacy during the study. A similar number of patients in each group withdrew from the study prematurely, but there were more dropouts due to adverse events in the clomipramine group. Concerning tolerability, there were significantly more reports of constipation and dry mouth in the clomipramine group. The results show that fluvoxamine and clomipramine have similar efficacy in the treatment of patients suffering from OCD, but fluvoxamine is better tolerated. In view of the superior safety profile of fluvoxamine compared to clomipramine in terms of a risk-benefit assessment, the use of fluvoxamine would appear to be advantageous for this patient population.
- Subjects :
- Adult
Anti-Anxiety Agents adverse effects
Antidepressive Agents, Tricyclic adverse effects
Clomipramine adverse effects
Double-Blind Method
Female
Fluvoxamine adverse effects
Humans
Male
Middle Aged
Treatment Outcome
Anti-Anxiety Agents therapeutic use
Antidepressive Agents, Tricyclic therapeutic use
Clomipramine therapeutic use
Fluvoxamine therapeutic use
Obsessive-Compulsive Disorder drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0268-1315
- Volume :
- 15
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International clinical psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 10759337
- Full Text :
- https://doi.org/10.1097/00004850-200015020-00002