[The role of arachidonic acid derivatives in generating membrane potential oscillations of the rat aorta endothelium].

Authors :: Marchenko SM
Source :: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) [Fiziol Zh (1994)] 2000; Vol. 46 (1), pp. 58-62.
Publication Year :: 2000
Abstract: Involvement of metabolites of arachidonic acid in electrical responses of rat aortic endothelium evoked by the agonist of aa1-adrenoreceptors, phenylephrine has been investigated. Our experiments suggest that phenylephrine evokes synthesis of thromboxane A2 in the rat aorta that is involved in the phenylephrine-evoked oscillations probably by increasing excitatory effect of the vasoconstrictor on vascular smooth muscle by the mechanism of positive feedback.

Subjects :: Adrenergic alpha-Agonists pharmacology
Animals
Aorta physiology
Endothelium, Vascular physiology
In Vitro Techniques
Membrane Potentials drug effects
Membrane Potentials physiology
Patch-Clamp Techniques
Phenylephrine pharmacology
Rats
Aorta drug effects
Arachidonic Acids physiology
Endothelium, Vascular drug effects

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