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Subthreshold symptoms and vulnerability indicators (e.g., eye tracking dysfunction) in schizophrenia.
- Source :
-
Comprehensive psychiatry [Compr Psychiatry] 2000 Mar-Apr; Vol. 41 (2 Suppl 1), pp. 86-9. - Publication Year :
- 2000
-
Abstract
- Subthreshold symptoms in schizophrenia can be prodromal signs of a psychotic relapse. In people without schizophrenia, similar symptoms may indicate the presence of disorders termed schizophrenia spectrum disorders. Subthreshold schizophrenia-like symptoms may indicate a genetically transmitted higher proneness to schizophrenia. Such a higher liability to develop schizophrenia is ascertained on a symptom level. In genetic studies, asymptomatic members of a pedigree are therefore classified as unaffected although they may possess the genes in question. On a biological level, eye tracking dysfunction has been shown to fulfill certain criteria for a vulnerability indicator and therefore promises to offer more information on genetically transmitted proneness to schizophrenia even in people without psychopathological symptoms. Subthreshold symptoms may warrant treatment. The database for prophylactic treatment in populations at high risk, especially those without symptoms, is currently very small.
- Subjects :
- Genetic Predisposition to Disease genetics
Humans
Risk Factors
Schizophrenia classification
Schizophrenia genetics
Schizotypal Personality Disorder classification
Schizotypal Personality Disorder genetics
Schizotypal Personality Disorder psychology
Pursuit, Smooth genetics
Saccades genetics
Schizophrenia diagnosis
Schizophrenic Psychology
Schizotypal Personality Disorder diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 0010-440X
- Volume :
- 41
- Issue :
- 2 Suppl 1
- Database :
- MEDLINE
- Journal :
- Comprehensive psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 10746909
- Full Text :
- https://doi.org/10.1016/s0010-440x(00)80013-9