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Melanocortin-1-receptor gene and sun sensitivity in individuals without red hair.
- Source :
-
Lancet (London, England) [Lancet] 2000 Mar 25; Vol. 355 (9209), pp. 1072-3. - Publication Year :
- 2000
-
Abstract
- Susceptibility to sunburn, photoageing, and skin cancer is inversely related to an individual's ability to tan after sun exposure. We examined variants in the melanocortin-1-receptor (MC1R) gene in individuals from Ireland and the UK. We found evidence of an association between the degree of tanning after repeated sun exposure, and the number of variant alleles present. Heterozygotes were intermediate between wild-type individuals and those with two variant alleles. We suggest that MC1R gene status therefore determines sun sensitivity in people without red hair.
- Subjects :
- Adult
Alleles
Female
Genetic Carrier Screening
Genotype
Humans
Ireland
Male
Receptors, Melanocortin
Risk Factors
United Kingdom
Hair Color genetics
Melanoma genetics
Neoplasms, Radiation-Induced genetics
Receptors, Corticotropin genetics
Skin Neoplasms genetics
Sunburn genetics
Ultraviolet Rays adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0140-6736
- Volume :
- 355
- Issue :
- 9209
- Database :
- MEDLINE
- Journal :
- Lancet (London, England)
- Publication Type :
- Report
- Accession number :
- 10744096
- Full Text :
- https://doi.org/10.1016/S0140-6736(00)02042-0