Back to Search
Start Over
Parallel synthesis of a series of subtype-selective NMDA receptor antagonists.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2000 Mar 20; Vol. 10 (6), pp. 527-9. - Publication Year :
- 2000
-
Abstract
- A series of 1-(heteroarylthioalkyl)-4-benzylpiperidines was rapidly synthesized through the use of parallel synthesis to investigate the binding affinity for the NR1A/2B receptor subtype.
- Subjects :
- Animals
Excitatory Amino Acid Antagonists pharmacology
Oxidopamine
Piperidines pharmacology
Rats
Structure-Activity Relationship
Sympathectomy, Chemical
Sympatholytics
Excitatory Amino Acid Antagonists chemical synthesis
Piperidines chemical synthesis
Receptors, N-Methyl-D-Aspartate antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 10
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 10741546
- Full Text :
- https://doi.org/10.1016/s0960-894x(00)00035-4