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Prognostic variables of papillary and follicular thyroid carcinoma patients with lymph node metastases and without distant metastases.
- Source :
-
Endocrine-related cancer [Endocr Relat Cancer] 1999 Mar; Vol. 6 (1), pp. 109-15. - Publication Year :
- 1999
-
Abstract
- From 1977 through 1995, 1,013 thyroid carcinoma patients received treatment and were followed up at Chang Gung Medical Center in Taiwan. To evaluate the prognostic variables of papillary and follicular thyroid carcinomas with limited lymph node metastases, a retrospective review of these patients was performed. Of these patients, 910 had papillary or follicular thyroid carcinoma, and 119 patients were categorized as clinical stage 2 with limited neck lymph node metastases only at the time of diagnosis. The patients were categorized into two groups as no recurrence and local recurrence or distant metastasis at the end of 1997. After the operations, radioactive iodide (131I) treatments were performed in 114 patients and external radiotherapy for neck region or distant metastases in 18 patients. The median follow-up period of these patients was 5.4 years. Clinical variables were coded in our computer for statistical analysis. After the treatments, 93 patients remained disease-free; 10 were in stage 2; 5 in stage 3; and 11 aggravated to stage 4. Of the clinical variables, age, post-operative first 1311 uptake scans, and 1-month post-operative thyroglobulin levels revealed statistically significant differences between the group which improved and the group which did not. During the follow-up period, five patients died; three patients died of thyroid cancer and two died of intercurrent diseases. Patients with papillary thyroid carcinoma revealed a higher percentage of lymph node metastases. Although limited lymph node metastases did not influence survival rate, patients with poor prognostic factors need more aggressive treatment to avoid progression of the cancer.
- Subjects :
- Adenocarcinoma, Follicular blood
Adenocarcinoma, Follicular pathology
Adenocarcinoma, Follicular radiotherapy
Adenocarcinoma, Follicular surgery
Adult
Biomarkers, Tumor
Carcinoma, Papillary blood
Carcinoma, Papillary pathology
Carcinoma, Papillary radiotherapy
Carcinoma, Papillary surgery
Disease Progression
Disease-Free Survival
Female
Follow-Up Studies
Humans
Iodine Radioisotopes therapeutic use
Lymphatic Metastasis
Male
Middle Aged
Neck Dissection
Neoplasm Metastasis
Neoplasm Proteins blood
Neoplasm Recurrence, Local
Neoplasm Staging
Prognosis
Radioisotope Teletherapy
Retrospective Studies
Survival Rate
Taiwan epidemiology
Thyroglobulin blood
Thyroid Neoplasms blood
Thyroid Neoplasms pathology
Thyroid Neoplasms radiotherapy
Thyroid Neoplasms surgery
Thyroidectomy
Treatment Outcome
Adenocarcinoma, Follicular mortality
Carcinoma, Papillary mortality
Thyroid Neoplasms mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1351-0088
- Volume :
- 6
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Endocrine-related cancer
- Publication Type :
- Academic Journal
- Accession number :
- 10732793
- Full Text :
- https://doi.org/10.1677/erc.0.0060109