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In vivo activities of the new anthelmintic depsipeptide PF 1022A.
- Source :
-
Parasitology research [Parasitol Res] 2000 Mar; Vol. 86 (3), pp. 194-9. - Publication Year :
- 2000
-
Abstract
- PF 1022A is a member of a new class of cyclic depsipeptides with antiparasitic activity. Following in vitro and laboratory animal studies it was tested for its anthelmintic efficacy in companion and livestock animals against a wide spectrum of intestinal nematodes and lungworms. Studies were carried out in rats, dogs, horses, sheep, and cattle. Animals were either naturally or experimentally infested. The efficacy of PF 1022A was investigated against the following parasite species: Strongyloides ratti and Nippostrongylus brasiliensis in rats, Ancylostoma caninum in dogs, small strongyles (cyathostomes) in horses, Trichostrongylus colubriformis and Haemonchus contortus in sheep, and Dictyocaulus viviparus in cattle. Doses varied from 1 to 10 mg/kg body weight for oral, subcutaneous or intravenous application in companion and livestock animals. High degrees of efficacy were found in all the above-cited examinations, and no clinical signs of intolerability were observed.
- Subjects :
- Animals
Cattle
Cattle Diseases drug therapy
Cattle Diseases parasitology
Dog Diseases drug therapy
Dog Diseases parasitology
Dogs
Feces parasitology
Helminthiasis, Animal parasitology
Horse Diseases drug therapy
Horse Diseases parasitology
Horses
Parasite Egg Count veterinary
Rats
Rodent Diseases drug therapy
Rodent Diseases parasitology
Sheep
Sheep Diseases drug therapy
Sheep Diseases parasitology
Animals, Domestic parasitology
Anthelmintics therapeutic use
Depsipeptides
Helminthiasis, Animal drug therapy
Peptides, Cyclic therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0932-0113
- Volume :
- 86
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Parasitology research
- Publication Type :
- Academic Journal
- Accession number :
- 10726989
- Full Text :
- https://doi.org/10.1007/s004360050031