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Effects of growth hormone administration on protein dynamics and substrate metabolism during 4 weeks of dietary restriction in obese women.
- Source :
-
Clinical endocrinology [Clin Endocrinol (Oxf)] 2000 Mar; Vol. 52 (3), pp. 305-12. - Publication Year :
- 2000
-
Abstract
- Objective: Treatment of obesity with very low calorie diet (VLCD) is complicated by protein loss. We evaluated the effects of coadministration of GH on protein turnover, substrate metabolism, and body composition in VLCD treated obesity.<br />Design and Patients: Fifteen obese women underwent 4 weeks of very low calorie diet (VLCD) in parallel with GH treatment (n = 7) or placebo (n = 8).<br />Measurements: Protein metabolism and total glucose turnover were isotopically assayed. Plasma concentrations of amino acids were determined by an HPLC system. Estimated rates of lipid and glucose oxidation were obtained by indirect calorimetry. Fat free mass was determined by DEXA-scan.<br />Results: Protein breakdown decreased in both groups (tyrosine flux micromol/h): -12% +/- 3 (GH) vs. - 9% +/- 3 (placebo)). Phenylalanine degradation in relation to phenylalanine concentration decreased by 9% in the GH group, whereas an increase of 8% was observed in the placebo group (P = 0.1). Plasma concentrations of several amino acids were significantly decreased in the placebo group, while urea excretion decreased in the GH group. A decrease in FFM was found in placebo treated patients (2.14% +/- 1.9 (GH) vs. - 3.54% +/- 1.6 (placebo), P < 0.05). Rates of lipid oxidation tended to be increased by GH treatment (lipid oxidation (mg/minutes): 79.7 +/- 5.9 (GH) vs. 64.6 +/- 5.9 (placebo), P = 0.1).<br />Conclusion: During dietary restriction GH primarily seems to conserve protein by a reduced hepatic degradation of amino acids.
- Subjects :
- Adult
Amino Acids blood
Analysis of Variance
Calorimetry, Indirect
Combined Modality Therapy
Double-Blind Method
Drug Administration Schedule
Female
Glucose metabolism
Human Growth Hormone therapeutic use
Humans
Injections, Subcutaneous
Lipid Metabolism
Lipid Peroxidation drug effects
Obesity metabolism
Urea urine
Dietary Carbohydrates administration & dosage
Human Growth Hormone administration & dosage
Obesity diet therapy
Obesity drug therapy
Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0300-0664
- Volume :
- 52
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 10718828
- Full Text :
- https://doi.org/10.1046/j.1365-2265.2000.00937.x