Back to Search Start Over

Effects of growth hormone administration on protein dynamics and substrate metabolism during 4 weeks of dietary restriction in obese women.

Authors :
Nørrelund H
Børglum J
Jørgensen JO
Richelsen B
Møller N
Nair KS
Christiansen JS
Source :
Clinical endocrinology [Clin Endocrinol (Oxf)] 2000 Mar; Vol. 52 (3), pp. 305-12.
Publication Year :
2000

Abstract

Objective: Treatment of obesity with very low calorie diet (VLCD) is complicated by protein loss. We evaluated the effects of coadministration of GH on protein turnover, substrate metabolism, and body composition in VLCD treated obesity.<br />Design and Patients: Fifteen obese women underwent 4 weeks of very low calorie diet (VLCD) in parallel with GH treatment (n = 7) or placebo (n = 8).<br />Measurements: Protein metabolism and total glucose turnover were isotopically assayed. Plasma concentrations of amino acids were determined by an HPLC system. Estimated rates of lipid and glucose oxidation were obtained by indirect calorimetry. Fat free mass was determined by DEXA-scan.<br />Results: Protein breakdown decreased in both groups (tyrosine flux micromol/h): -12% +/- 3 (GH) vs. - 9% +/- 3 (placebo)). Phenylalanine degradation in relation to phenylalanine concentration decreased by 9% in the GH group, whereas an increase of 8% was observed in the placebo group (P = 0.1). Plasma concentrations of several amino acids were significantly decreased in the placebo group, while urea excretion decreased in the GH group. A decrease in FFM was found in placebo treated patients (2.14% +/- 1.9 (GH) vs. - 3.54% +/- 1.6 (placebo), P < 0.05). Rates of lipid oxidation tended to be increased by GH treatment (lipid oxidation (mg/minutes): 79.7 +/- 5.9 (GH) vs. 64.6 +/- 5.9 (placebo), P = 0.1).<br />Conclusion: During dietary restriction GH primarily seems to conserve protein by a reduced hepatic degradation of amino acids.

Details

Language :
English
ISSN :
0300-0664
Volume :
52
Issue :
3
Database :
MEDLINE
Journal :
Clinical endocrinology
Publication Type :
Academic Journal
Accession number :
10718828
Full Text :
https://doi.org/10.1046/j.1365-2265.2000.00937.x