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Comparative biokinetics of plutonium and americium after inhalation of PuO2 and mixed oxides (U, Pu)O2 in rat.
- Source :
-
International journal of radiation biology [Int J Radiat Biol] 2000 Feb; Vol. 76 (2), pp. 215-22. - Publication Year :
- 2000
-
Abstract
- Purpose: To compare the biokinetics of Pu and Am in rat after inhalation of PuO2 and two (U, Pu) mixed oxides (MOX), referred to as MIMAS and SOLGEL.<br />Materials and Methods: Lung clearance was measured in vivo by X-and y-ray spectrometry. Retention of Pu and Am in femurs, liver and kidneys was measured by alpha-spectrometry.<br />Results: Observed lung clearance was in the same range for all three powders. Extra-pulmonary transfers were expressed as the percent of the initial deep lung deposit (IDLD) measured 7 days after inhalation. After PuO2 exposure, bone retention remained nearly constant throughout the 270-day experiment. It was approximately 0.7% of the IDLD for Pu and Am. By contrast, a gradual increase was observed for the two MOX. After 7 days, bone retention of Pu and Am was respectively 0.05 and 0.08% for MIMAS, and 0.2 and 0.6% for SOLGEL. The retention reached maximal values between 180 and 270 days post-exposure, which were 0.2 and 0.3% for MIMAS, and 1.2 and 2.8% for SOLGEL for Pu and Am respectively.<br />Conclusions: Different transfer rates of Pu and Am from the lung were observed depending on the chemical composition of the oxides and/or the method of their preparation.
Details
- Language :
- English
- ISSN :
- 0955-3002
- Volume :
- 76
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of radiation biology
- Publication Type :
- Academic Journal
- Accession number :
- 10716642
- Full Text :
- https://doi.org/10.1080/095530000138862