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Comparative biokinetics of plutonium and americium after inhalation of PuO2 and mixed oxides (U, Pu)O2 in rat.

Authors :
Ramounet B
Matton S
Guezingar-Liebard F
Abram MC
Rateau G
Grillon G
Fritsch P
Source :
International journal of radiation biology [Int J Radiat Biol] 2000 Feb; Vol. 76 (2), pp. 215-22.
Publication Year :
2000

Abstract

Purpose: To compare the biokinetics of Pu and Am in rat after inhalation of PuO2 and two (U, Pu) mixed oxides (MOX), referred to as MIMAS and SOLGEL.<br />Materials and Methods: Lung clearance was measured in vivo by X-and y-ray spectrometry. Retention of Pu and Am in femurs, liver and kidneys was measured by alpha-spectrometry.<br />Results: Observed lung clearance was in the same range for all three powders. Extra-pulmonary transfers were expressed as the percent of the initial deep lung deposit (IDLD) measured 7 days after inhalation. After PuO2 exposure, bone retention remained nearly constant throughout the 270-day experiment. It was approximately 0.7% of the IDLD for Pu and Am. By contrast, a gradual increase was observed for the two MOX. After 7 days, bone retention of Pu and Am was respectively 0.05 and 0.08% for MIMAS, and 0.2 and 0.6% for SOLGEL. The retention reached maximal values between 180 and 270 days post-exposure, which were 0.2 and 0.3% for MIMAS, and 1.2 and 2.8% for SOLGEL for Pu and Am respectively.<br />Conclusions: Different transfer rates of Pu and Am from the lung were observed depending on the chemical composition of the oxides and/or the method of their preparation.

Details

Language :
English
ISSN :
0955-3002
Volume :
76
Issue :
2
Database :
MEDLINE
Journal :
International journal of radiation biology
Publication Type :
Academic Journal
Accession number :
10716642
Full Text :
https://doi.org/10.1080/095530000138862