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Crystallization and preliminary X-ray diffraction studies of d(ACGTAGCTACGT)2:[actinomycin D, (echinomycin)2] and d(ACGTAGCTACGT)2:[actinomycin D, (triostin A)2] complexes.
- Source :
-
Acta crystallographica. Section D, Biological crystallography [Acta Crystallogr D Biol Crystallogr] 2000 Mar; Vol. 56 (Pt 3), pp. 344-7. - Publication Year :
- 2000
-
Abstract
- A DNA-multiple drug complex, d(ACGTAGCTACGT)(2):[actinomycin D, (echinomycin)(2)] has been crystallized. The crystals belong to the monoclinic space group C2, with unit-cell parameters a = 85.6, b = 72.8, c = 56.6 A, beta = 101.5 degrees at 93 K and Z = 8. The crystal diffracted to 3.0 A resolution along the DNA fiber axis and to 3.5 A resolution in other directions. The Patterson maps indicate that all complexes in the crystal are oriented along their helical axes in the [101;] direction.
- Subjects :
- Crystallization
Crystallography, X-Ray
Dactinomycin metabolism
Echinomycin metabolism
Macromolecular Substances
Models, Molecular
Molecular Conformation
Molecular Structure
Oligodeoxyribonucleotides metabolism
Quinoxalines chemistry
Quinoxalines metabolism
Dactinomycin chemistry
Echinomycin chemistry
Oligodeoxyribonucleotides chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0907-4449
- Volume :
- 56
- Issue :
- Pt 3
- Database :
- MEDLINE
- Journal :
- Acta crystallographica. Section D, Biological crystallography
- Publication Type :
- Academic Journal
- Accession number :
- 10713522
- Full Text :
- https://doi.org/10.1107/s0907444999016790