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Determinants of quantitative spectral electroencephalography in early Alzheimer's disease: cognitive function, regional cerebral blood flow, and computed tomography.
- Source :
-
Dementia and geriatric cognitive disorders [Dement Geriatr Cogn Disord] 2000 Mar-Apr; Vol. 11 (2), pp. 81-9. - Publication Year :
- 2000
-
Abstract
- Electroencephalography (EEG) bands may have different clinical or physiological correlates at initial diagnosis of Alzheimer's disease (AD). We studied 163 consecutive patients with probable (n = 105) and possible (n = 58) AD with measurements of cognitive function (CAMCOG), regional cerebral blood flow (rCBF) with single photon emission computed tomography using technetium-99m-labeled hexamethylpropylene amine oxime, and computed tomography (CT). Lower CAMCOG scores were significantly and most strongly associated with lower parieto-occipital and fronto-central alpha power. In a separate analysis of cognitive domains, disturbances in language, praxis, attention, and abstraction were also significantly and most consistently related to decrease in alpha power. Presence of cortical atrophy as measured on CT showed some statistically significant relations with EEG bands, but these associations were not consistent. Lower temporal and parietal rCBF were significantly related to lower parieto-occipital alpha activity. Presence of leukoaraiosis was significantly associated with lower beta values, but also with higher absolute theta and delta activity. The results suggest that alpha on EEG is most closely linked to cognitive function and rCBF, while beta and theta activity more likely reflect lower cortical or subcortical changes. Our study thus provides evidence that the EEG bands reflect differential pathophysiologic changes in AD.<br /> (Copyright 2000 S. Karger AG, Basel)
- Subjects :
- Aged
Aged, 80 and over
Alzheimer Disease diagnostic imaging
Alzheimer Disease psychology
Atrophy
Female
Humans
Male
Radiopharmaceuticals
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon
Tomography, X-Ray Computed
Alzheimer Disease physiopathology
Cerebrovascular Circulation physiology
Cognition physiology
Electroencephalography
Subjects
Details
- Language :
- English
- ISSN :
- 1420-8008
- Volume :
- 11
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Dementia and geriatric cognitive disorders
- Publication Type :
- Academic Journal
- Accession number :
- 10705165
- Full Text :
- https://doi.org/10.1159/000017219